The objective of present study was developing gastro retentive drug delivery system of ofloxacin. Retention of drug delivery system in the stomach prolongs overall GI transit time, there by resulting in improved absorption and bioavailability of ofloxacin. Present investigation highlights the formulation and characterization of floating microspheres of ofloxacin. Ofloxacin is the first generation fluroquinolone. The plasma half-life of drug is approximately 4-5 Hrs. The Floating microspheres of ofloxacin were prepared by solvent diffusion technique using polymer such as ethyl cellulose, HPMC K4M and PVA in a different ratio. The prepare microsphere were subjected to evaluation for physical characteristics like particle size percent drug entrapment, buoyancy test and In-vitro release study. The result of all physicochemical tests for all formulation was found to be satisfactory. The In-vitro drug releases were found to be in the range of 40% to 94% at the end of 6 hrs.
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